http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S6445336-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b9822bceff022feda91b10019125e70f |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-367 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C59-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B53-00 |
| filingDate | 1987-08-13^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4843a65aa716b2fb37b4f1f751ed262d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86515d63568cc02df8c9e19c0bc2133f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c438532f7cce113888a938d9bd14e11d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d0262ab15cc125daf78bdda388f7fa93 |
| publicationDate | 1989-02-17^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S6445336-A |
| titleOfInvention | Production of 2-(r)-hydroxy-4-phenyllactic acid derivative |
| abstract | PURPOSE:To readily obtain the titled compound at a low cost and large amounts without complicated treatment such as optical resolution, by reacting an optically active N-carbamoyl-2-(R)-amino-phenyllactic acid used as a raw material with a diazotizing agent and then subjecting the resultant product to esterification reaction. CONSTITUTION:An optically active N-carbamoyl-2-(R)-amino-4-phenyllactic acid expressed by formula II obtained by subjecting D,L-5-phenetylhydantoin expressed by formula I to enzymic and asymmetric hydrolysis is used as a raw material and reacted with a diazotizing agent such as NaNO2, preferably in an acidic aqueous solution such as sulfuric acid having concentration of 0.3-3.0 normality in acidity at 0-150 deg.C, preferably 0-100 deg.C and successively subjected to esterification reaction according to a normal method to provide the aimed compound expressed by formula IV (R is R<2>) useful as a synthetic raw material for N-substituted -L-amino acid derivative expressed by formula III (R<1> is lower alkyl; R<2> is H or protecting group of carboxyl group) which is a producing intermediate for angiotensin conversion enzyme inhibiting agent, etc. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2305734-A1 |
| priorityDate | 1987-08-13^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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