| abstract |
(In the formula, n represents an integer of 0 to 3, and R 1 represents substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted alicyclic heterocyclic group, or substituted or unsubstituted aromatic. R 2 represents halogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted alicyclic heterocyclic group, substituted or unsubstituted aromatic heterocyclic group, -COR 8 or the like, R 3 and R 4 are the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl, -COR 12 or the like) For example, an adenosine A 2A receptor antagonist containing the thiazole derivative represented by the above general formula (I) or a pharmacologically acceptable salt thereof as an active ingredient is provided. |