| abstract |
Formula (I) [Where: Represents a single bond or a double bond, Ar 1 represents a phenyl group or a pyridinyl group which may be substituted with 1 to 3 substituents, R 1 and R 2 represent a C 1-6 alkyl group, a hydroxyl group, etc. Z 1 represents an optionally substituted methylene group or vinylene group, an oxygen atom or an imino group optionally substituted by a C 1-6 alkyl group or a C 1-6 acyl group, and p, q and r are An integer of 0 to 2 is shown. The bicyclic cinnamamide compound represented by the above formula is useful as a prophylactic or therapeutic agent for neurodegenerative diseases caused by Aβ such as Alzheimer's disease and Down's syndrome because it has an Aβ40 and Aβ42 production lowering effect. |