http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100409099-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-11 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12 |
| filingDate | 1997-04-15^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2003-12-11^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2003-12-11^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-100409099-B1 |
| titleOfInvention | Device for treating nerve damage |
| abstract | The present invention relates to glial cell line-derived neurotrophic factor (GDNF), which is a potent neurotropin that exhibits a broad spectrum of biological activity against various cell types in the central and peripheral nervous systems. The present invention also relates to the cloning of a receptor having high affinity for GDNF, its features and neurological damage therapeutic apparatus using the same. It was named GDNF receptor (GDNFR) because it is the first known component in the receptor system. Described herein are nucleic acid sequences and amino acid sequences of GDNFR protein products. Hydrophobic domains that function as signal peptides are found at the amino terminus, while the second hydrophobic domain at the carboxy terminus is involved in receptor binding to the cell membrane. The lack of a transmembrane domain and cytoplasmic site indicates that GDNFR requires one or more accessory molecules to mediate the transmembrane signal. GDNFR mRNA is widely distributed in the nervous system and non-neural tissues and is similar to the GDNF distribution. |
| priorityDate | 1996-04-22^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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