http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101157468-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D317-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-16 |
| filingDate | 2005-02-03^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2012-07-06^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2012-07-06^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-101157468-B1 |
| titleOfInvention | 1,3-dioxolane nucleoside preparation method |
| abstract | The present invention provides a process for preparing enantiomerically pure β-D-dioxolane nucleosides. In particular, novel synthesis of (-)-DAPD, suitable for large scale development, is preferred. In one embodiment, the present invention provides a method for preparing or obtaining esterified 2,2-dialkoxy ethanol; b) cyclizing 2,2-dialkoxy ethanol esterified with glycolic acid to give 1,3-dioxolane lactone; c) dissolving 1,3-dioxolane lactone to obtain substantially pure D- or L-lactone; d) selectively reducing and activating D- or L-chiral lactone to obtain substantially pure D- or L-1,3-dioxolane; e) linking D- or L-1,3-dioxolane to an activated and / or protected purine or pyrimidine base; f) substantially pure β-D or β-L-1, comprising optionally purifying the nucleosides to yield substantially pure protected β-D or β-L-1,3-dioxolane nucleosides Provided are methods for preparing, 3-dioxolane nucleosides. |
| priorityDate | 2004-02-03^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Showing number of triples: 1 to 380 of 380.