abstract |
The present invention relates to novel isoxazole-pyridine derivatives of formula (I) and their pharmaceutically acceptable salts and esters: Formula I In this formula, X, R 1 , R 2 , R 3 and R 4 are as defined herein. The active compounds of the present invention have affinity and selectivity for the gamma-aminobutyric acid (GABA) A [alpha] 5 receptor. The invention also relates to a process for the preparation of the active compounds of the formula I, pharmaceutical compositions containing them and their use as medicaments. |