| abstract |
A naphthalenecarboxamide derivative, a production method thereof, and use thereof. Its structure is represented by the formula (I), and the definitions of R 1 , R 2 , R 3 , R 4 and Z are the same as those described in this specification. The compound has both a protein kinase inhibitory activity and a histone deacetylase inhibitory activity and is useful for the treatment and / or prophylaxis of inflammation, autoimmune diseases, cancer, neurological diseases and neurodegenerative diseases, cardiovascular diseases, metabolic diseases, allergies, asthma and hormone- Protein kinase activity abnormality or histone deacetylase activity abnormality. |