| abstract |
In many embodiments of the present invention, the present invention provides certain iminothiadiazine dioxide compounds comprising a compound of formula I, including stereoisomers thereof, and pharmaceutically acceptable salts of said compounds and stereoisomers . (I) Wherein each of R 1 , R 2 , R 3 , R 4 , R 5 , R 9 , ring A, ring B, m, n, p, -L 1 -, L 2 - and L 3 - And are as defined herein. The novel iminothiadiazine dioxide compounds of the present invention have surprisingly been found to exhibit properties that are expected to make them advantageous for the treatment or prevention of various pathological conditions associated with BACE inhibitors and / or production of [beta] -amyloid (A [beta] . Also disclosed are pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), methods of making the same, and the use of treatment of pathologies associated with amyloid beta (A [beta]) proteins, including Alzheimer's disease . |