abstract |
The present invention relates to substituted compounds having the formula (I), stereoisomers thereof and / or pharmaceutically acceptable salts thereof: Wherein R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are as described herein. The present invention also relates to methods of making these compounds, including intermediates thereof. The compounds of the present invention are effective at the kappa (kappa) opioid receptor (KOR) site. Accordingly, the compounds of the present invention are useful as medicaments for the treatment and / or prevention of various central nervous system (CNS) diseases, particularly at the periphery in the CNS, including, but not limited to, acute and chronic pain and related diseases. |