| abstract |
The present invention relates to compounds of formula I: [Formula I] In the above formula, ring A is phenyl, naphthalenyl, pyridyl, quinolinyl, isoquinolinyl, imidazopyridyl, furanyl, thiazolyl, isoxazolyl, pyrazolyl, imidazothiazolyl, benzimida Zolyl or indazolyl; R 1 is H, alkyl, alkoxy, hydroxyalkylene, OH, halo, phenyl, triazolyl, oxazolyl, isoxazolyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, piperazinyl, pyra Zolyl, oxadiazolyl, pyrrolidinyl, thiophenyl, morpholinyl or dialkylamino; R 2 is H, alkyl, alkoxy, hydroxyalkylene or halo; Z is NH, N-alkyl or O; R 5 is pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, quinazolinyl, quinoxalinyl, pyrazolyl optionally substituted with one or two substituents independently selected from the group consisting of alkyl, alkoxy or halo , Benzoxazolyl, imidazopyrazinyl, triazolopyrazinyl; n is 0 or 1. Methods for the preparation of compounds of formula I are also described. The invention also relates to pharmaceutical compositions comprising a compound of formula (I). Methods of using the compounds of the present invention are also within the scope of the present invention. |