| abstract |
The present application relates to novel substituted (aza)pyridopyrazolopyrimidinones and indazolopyrimidinones, methods for their preparation, treatment and/or prophylaxis of diseases, in particular with or without underlying hereditary or acquired bleeding disorders. to a compound for use alone or in combination in a method for the treatment and/or prevention of acute and recurrent bleeding in a patient, wherein the bleeding is hypermenorrhea, postpartum hemorrhage, hemorrhagic shock, trauma, surgery, transplantation, stroke, associated with a disease or medical intervention selected from the group consisting of liver disease, hereditary angioedema, epistaxis, and synovitis and cartilage damage after angiogenesis. |