| abstract |
The present invention relates to a composition comprising a polyplex formulation for delivery of RNA to a target organ or target cell after parenteral administration, particularly after intramuscular administration. More particularly, the present invention relates to formulations for administration of RNA such as self-replicating RNA, in particular formulations by intramuscular injection. More specifically, the formulation comprises polyplex particles from single-stranded RNA and polyalkyleneimine. The RNA may encode a protein of interest, such as a pharmaceutically active protein. The present invention also relates to a pharmaceutical product comprising said RNA polyplex formulation for parenteral application to humans or animals. The invention also relates to the manufacture of such medicaments, optionally comprising the steps of aseptic filtration, freezing and dehydration. |