| abstract |
The present invention provides a compound of formula (I), or a pharmaceutically acceptable salt thereof.n n n (I)n n n n n n n n Wherein,n n n Z is OH, C 1-6 alkoxy, -NR 2 R 3 or heterocycle; Q is selected from the group consisting of (a) phenyl which may be substituted, (b) a 6-membered monocyclic aromatic group which may be substituted, containing 1, 2, 3 or 4 nitrogen atoms, (c) A 5-membered monocyclic aromatic group which contains 1 hetero atom and may contain 1, 2 or 3 nitrogen atoms other than the hetero atom, and which may be substituted; (d) C 3-7 cycloalkyl which may be substituted; And (e) a benzo-fused heterocycle which may be substituted; R 1 is hydrogen, C 1-4 alkyl or halo; R 2 and R 3 are independently H, OH, C 1-4 alkoxy, C 1-4 alkyl, or C 1-4 alkyl substituted with halo, OH, C 1-4 alkoxy, or CN; X is selected from the group consisting of H, halo, C 1-4 alkyl, halo-substituted C 1-4 alkyl, OH, C 1-4 alkoxy, halo-substituted C 1-4 alkoxy, C 1-4 alkylthio, NO 2 , NH 2 , di- (C 1-4 alkyl) amino, and CN; n is 0, 1, 2, 3 or 4; The present invention also provides a pharmaceutical composition useful for the treatment of a medical disorder in which prostaglandin is involved as a pathogen. |