| abstract |
The present invention relates to benzofuran derivatives having the formula (1), enantiomers thereof and pharmaceutically acceptable acid addition salts thereof. The compound binds effectively with the 5-HT 1A receptor.n n n (Formula 1)n n n n n n n n Here, A is selected from formula (2), formula (3), formula (4) and formula (5).n n n (Formula 2)n n n n n n n n (Formula 3)n n n n n n n n (Formula 4)n n n n n n n n (Formula 5)n n n n n n n n Wherein Z is O or S; s is 0 or 1; q is 0 or 1; R 4 is hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkyl-aryl or C 1-6 alkyl-O-aryl; D is a spacer group selected from branched or straight chain C 1-6 alkylene, C 2-6 alkenylene and C 2-6 alkynylene. |