| abstract |
The present invention provides a liver disease prevention and treatment agent and hepatic stromal cell activation inhibitor containing a compound having Rho kinase inhibitory activity. Compounds having Rho kinase inhibitory activity, such as (+)-trans-4- (1-aminoethyl) -1- (4-pyridylcarbamoyl) cyclohexane, have an excellent inhibitory effect on hepatic stellate cell activation, Since it has various actions such as inhibitory action on liver fibrosis in liver tissue, it is useful for preventing and treating liver diseases such as hepatitis and liver fibrosis. |