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publicationDate 2002-10-05^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber KR-20020075579-A
titleOfInvention Novel method for preparing optically active pyridobenzoxazine carboxylic acid derivatives
abstract The present invention relates to a novel process for the preparation of optically active pyridobenzoxazine carboxylic acid derivatives, comprising the application of a hydrolase purified from microorganisms or microorganisms to an opoxacin ester derivative which is a racemic mixture. Selectively hydrolyzing the floxacin ester derivative, separating the unhydrolyzed (S) -ofloxacin ester derivative, and hydrolyzing the isolated (S) -ofloxacin ester derivative It provides a method for producing a pyridobenzoxazine carboxylic acid derivative. Here, the microorganism that selectively hydrolyzes the (R) -ofloxacin ester derivative is Bacillus niacini EM001 (Accession No. KCTC 0965BP). The method of the present invention is a pyrodobenz having an optical activity by selectively removing the (R) -type ofloxacin ester with high selectivity as a simple, economical and environmentally friendly bioconversion technology. Oxazine carboxylic acid derivatives can be prepared in high yields.
priorityDate 2001-03-26^^<http://www.w3.org/2001/XMLSchema#date>
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