| abstract |
The present invention relates generally to compounds of formula (I) as muscarinic M2 / M3 receptor antagonists:n n n Formula In n n n n n n n Wheren n n One of X, Y or Z is independently —S—, —O— or> NR 4 and the other two are —CH 2 —;n n n p is an integer from 0 to 3;n n n m is an integer from 0 to 3;n n n n is an integer from 1 to 6;n n n R 3 is (C 1-6 ) -alkyl, (C 1-6 ) -alkenyl, (C 1-6 ) -alkynyl or cycloalkyl;n n n R 1 , R 2 and R 3 are hydrogen or certain substituents.n n n The compounds are useful for treating diseases associated with smooth muscle disorders. |