| abstract |
The present disclosure discloses and claims the compounds of the formula (I) as well as their pharmaceutically acceptable salts and their use in pharmaceutical compositions and therapies, in particular in the management of pain, anxiety and functional gastrointestinal disorders:n n n <Formula I>n n n n n n n n Wherein R 1 is selected from any one of phenyl, pyridinyl, pyrrolyl, thienyl, furanyl, imidazolyl, triazolyl and pyridyl-N-oxide, wherein each R 1 phenyl ring And R 1 heteroaromatic ring is 1, 2 or 3 substituents selected from straight and branched C 1 -C 6 alkyl, NO 2 , CF 3 , C 1 -C 6 alkoxy, chloro, fluoro, bromo and iodo May be optionally substituted independently and independently, substitution on the phenyl ring and the heteroaromatic ring may occur at any position on the ring system). |