| abstract |
The present invention relates to compounds of formula I:n n n [Formula I]n n n n n n n n (Wherein,n n n W is N, CR 3 or sp 2 hybridized carbon atom,n n n E is, together with W, a 3- to 7-membered saturated carbocyclic having from 0 to 3 N atoms, from 0 to 2 atoms and / or from 0 to 2 atoms of S, wherein the ring may comprise a double bond or Heterocyclic ring,n n n D is mono- or polysubstituted with Hal, A, OR 3 , N (R 3 ) 2 , NO 2 , CN, COOR 3 or CON (R 3 ) 2 , or N, O and / or S atoms Monocyclic or bicyclic, aromatic unsubstituted aromatic carbocycle or heterocycle, 0-4;n n n G is-[C (R 4 ) 2 ] n -,-[C (R 4 ) 2 ] n NR 3 -,-[C (R 4 ) 2 ] n O-,-[C (R 4 ) 2 ] n S- or-[C (R 4 ) = C (R 4 )] n- ,n n n X is-[C (R 4 ) 2 ] n CONR 3 [C (R 4 ) 2 ] n -,-[C (R 4 ) 2 ] n NR 3 CO [C (R 4 ) 2 ] n -,- [C (R 4 ) 2 ] n NR 3 [C (R 4 ) 2 ] n -,-[C (R 4 ) 2 ] n O [C (R 4 ) 2 ] n -,-[C (R 4 ) 2] n CO [C ( R 4) 2] n - , and -, or - [C (R 4) 2 ] n COO [C (R 4) 2] nn n n Y is alkylene, cycloalkylene, Het-diyl or Ar-diyl,n n n T is mono- or polysubstituted with = O, = S, = NR 3 , = N-CN, = N-NO 2 , = NOR 3 , = NCOR 3 , = NCOOR 3 , = NOCOR 3 ,n n n R 3 , Hal, A,-[C (R 4 ) 2 ] n -Ar,-[C (R 4 ) 2 ] n -Het,-[C (R 4 ) 2 ] n -cycloalkyl, OR 3 , N (R 3 ) 2 , NO 2 , CN, COOR 3 , CON (R 3 ) 2 , NR 3 COA, NR 3 CON (R 3 ) 2 , NR 3 SO 2 A, COR 3 , SO 2 NR 3 and Mononuclear or heteronuclear, saturated or unsaturated carbocycle or heterocycle, having 0 to 4 atoms of N, O and / or S, which may be mono-, di- or tri-substituted with S (O) n A, andn n n R 1 And R 2 are as defined in claim 1). The compounds of the present invention inhibit coagulation factor Xa and can be used for the prophylaxis and / or treatment of thromboembolic diseases and for the treatment of tumors. |