| abstract |
This invention provides branched water-soluble pollymers that allow two species of water soluble polymer to be conjugated to another species.n n n The water soluble branched polymer provides access to therapeutic agents conjugated at a single site of two species of water soluble polymer.n n n The water soluble branched polymer is based on branched points with simple peptide alkyl structures, reactive branched amino acids and small peptides and saccharides of reactive cyclic amino acids.n n n In addition, a method of producing a mono-disperse poly (ethylene glycol) capable of measuring a molecular weight with a clear structure and a method of functionalizing a poly (ethylene glycol) dml rational end is described. to provide. It also provides conjugates of various species, namely peptides, lipids, glyco lipids, and water soluble branched polymers with small molecules. |