| abstract |
The present invention relates to novel compounds having a variety of therapeutic uses, and more particularly to novel substituted cyclic alkylidene compounds that are particularly useful for selective estrogen receptor modulation. Compounds of formula (I) and salts, solvent compounds and pharmacologically functional derivatives thereof are included:n n n n n n n n In which R 1 is OH; R 2 and R 4 are each independently selected from OH, alkyl or halogen; p and q are each independently selected from 0, 1 or 2; R 3 is-(Y) z -R 8 ; z is 0 or 1; Y is -C≡C- or -CR 6 = CR 1- ; X is-(CH 2 ) n- , where n is 0, 1, 2 or 3, -C (R 9 ) 2- , -O- or -S-. |