| abstract |
In general, the invention features genetically modified non-human mammals (eg, bovine and other ungulates), and methods of making these mammals. In particular, the invention features transgenic ungulates having reduced levels of endogenous IgM heavy chains and / or prion proteins.n n n n Endogenous IgM heavy chain, prion, mad cow disease, transgenic ungulate, genetic engineering, genetic modification, denuclear egg |