| abstract |
A compound of formula (I), an N-oxide, salt, or stereoisomer thereof (A represents OR 1 , NHS (═O) p R 2 ; wherein R 1 is hydrogen, C 1 -C 6 alkyl, C 0 -C 3 alkylenecarbocyclyl, C 0 -C 3 alkyleneheterocyclyl; R 2 is C 1 -C 6 alkyl, C 0 -C 3 alkylenecarbocyclyl, C 0 -C 3 alkylene Heterocyclyl; p independently represents 1 or 2; n represents 3, 4, 5 or 6; ----- represents any double bond; L represents N or CRz; Rz Is H or forms a double bond with an asterisk carbon; Rq is H, or when L is CRz, Rq may be C 1 -C 6 alkyl; Rr is C 1 -C 6 alkyl, C 1 -C 6 alkoxy, hydroxy, halo, haloC 1 -C 6 alkyl, amino, mono- or dialkylamino, mono- or dialkylaminocarbonyl, C 1 -C 6 alkylcarbonyl-amino, C 0 -C 3 Alkylene Carbocyclyl and C 0 -C 3 Alkylene Heterocyclo Quinazolinyl optionally substituted with one or two or three substituents each independently selected from kyl; R 5 represents hydrogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxyC 1 -C 6 alkyl or C 3- C 7 cycloalkyl; R 6 represents hydrogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 0 -C 3 alkylenecarbocyclyl, C 0 -C 3 alkyleneheterocyclyl, hydroxy , Bromo, chloro or fluoro) have utility in the treatment or prevention of flaviviruses, such as HCV infection. |