| abstract |
The present invention provides a sustained analgesic effect of a crosslinked hyaluronic acid derivative, in which some of the functional groups of the hyaluronic acid are crosslinked with the crosslinker at a crosslinking ratio of 0.6% to 15% relative to the total number of disaccharide unit components of the hyaluronic acid. Injectable solutions for intraarticular administration for the treatment of arthritis diseases, comprising together with a pharmaceutically acceptable carrier in an amount having a cartilage caused by arthritis disease, including the cross-linked hyaluronic acid derivative and a pharmaceutically acceptable carrier It relates to a composition for inhibiting regression, or a composition for inhibiting inflammation of cartilage degeneration or synovial membrane.n n n Arthritis diseases, cross-linked hyaluronic acid derivatives, long lasting |