| abstract |
The present invention provides a chemical formula I having a potent COMT inhibitory action Formula I [Wherein, R 1 and R 2 are each hydrogen, lower acyl, lower alkoxycarbonyl and the like; R 3 is halo lower alkyl, lower acyl, halo lower alkylcarbonyl, cycloalkylcarbonyl, optionally substituted arylcarbonyl, lower alkoxycarbonyl and the like; R 4 is lower alkyl, halo lower alkyl, cycloalkyl, lower alkoxy lower alkyl, or the like, or a pharmacologically acceptable salt thereof, a pharmaceutical composition containing the same, and a use thereof. |