| abstract |
The present invention comprises at least one pharmaceutical active ingredient, excluding opioids, wherein the core is coated by at least one coating layer that controls the release of the pharmaceutical composition, the coating layer being based on i) the dry weight of the polymer mixture. 40-95 wt.% Of at least one vinyl polymer or copolymer that is water insoluble and essentially neutral, and ii) 5 to 60 wt.%, Based on the dry weight of the polymer mixture, insoluble in buffer media below pH 4.0. And a polymer mixture of at least one anionic polymer or copolymer that is soluble at least in the range of pH 7.0 to pH 8.0, wherein the coating layers are each 110-250% by weight of non-porous, calculated based on the dry weight of the polymer mixture. Further comprising an inert lubricant, 1 to 35% by weight of at least one neutral cellulose compound and 1 to 25% by weight of at least one emulsifier , It relates to a pH- dependent controlled release pharmaceutical composition, comprising a step of. |