| abstract |
The present invention relates to a novel compound that inhibits HIF-1α activity, a preparation method thereof, a pharmaceutical composition comprising the same, and the like. The compound according to the present invention may be used as a prophylactic and / or therapeutic agent for various solid cancer diseases such as colon cancer, liver cancer, gastric cancer, and breast cancer by inhibiting HIF-1α activity, and also expressing VEGFA by HIF-1α in a hypoxic state. It is expected that the present invention may be used to develop and prevent and / or treat diabetic retinopathy or rheumatoid arthritis. |