| abstract |
The present invention relates to novel 5-amino-3,6-dihydro-1H-pyrazin-2-one derivatives as beta-secretase inhibitors, also known as beta-site amyloid cleavage enzymes, BACE, BACE1, Asp2 or memacin2. It is about. The invention also relates to pharmaceutical compositions comprising the compounds, methods of making the compounds and compositions, and Alzheimer's disease (AD), mild cognitive impairment, senility, dementia, Lewy body dementia, Down syndrome, stroke related dementia, Parkinson's disease The present invention relates to the use of such compounds and compositions for preventing and treating diseases involving beta-secretase, such as dementia or beta-amyloid related dementia. |