| abstract |
Formula (B n -CS o -I s -CS p -FC-CS q -I t -CS r -B m) u {B is non when n- mer biologically active and expression and absence of Fc- fusion site as Wherein FC represents a heavy chain Fc-site polypeptide, CS represents a cleavage site, I represents an intervening amino acid sequence, FC does not substantially bind to an Fc-receptor A method for producing a biologically active polypeptide as a n-dimer comprising a nucleic acid encoding a fusion polypeptide according to claim 1, comprising recovering the fusion polypeptide from the cell or culture medium, optionally digesting the fusion polypeptide with a protease, Lt; RTI ID = 0.0 > Fc-site < / RTI > is expressed as a non-specific aggregate / multimer. |