| abstract |
A novel fibrinogen-based tissue adhesion patch is described. The patch comprises a back surface made from a non-permeable biocompatible polymer film incorporated with a piggibronogen-based sealant. In a preferred embodiment of the invention, the fibrinogen-based sealant comprises fibrinogen, thrombin and CaCl 2. The polymer backing serves to seal the tissue to which the patch is applied, and the sealant only acts to bind the patch to the affected tissue. The patches do not include any mesh or woven components. A method of generating a patch is also described. |