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filingDate 2015-07-24^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_79bf4e94ea5ad469623119ec18517ced
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publicationDate 2017-03-31^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber KR-20170035941-A
titleOfInvention Purification platform for bispecific antibodies
abstract High resolution protein A chromatography using chaotropic agonists and pH gradient or pH step elution buffers produces improved peak resolution between closely related molecular species. A bispecific antibody containing a protein A-binding-removed substituted CH3 domain paired with a protein A-binding CH3 domain is a protein A-binding-deleted CH3 domain pairing with a protein A-binding-removed substituted CH3 domain with high peak resolution, A single specific antibody containing a deduced substituted CH3 domain and a protein A-linked CH3 domain paired with a protein A-linked CH3 domain. Useful chaotropic agonists include magnesium chloride and calcium chloride.
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20210084054-A
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priorityDate 2014-07-26^^<http://www.w3.org/2001/XMLSchema#date>
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