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filingDate 2016-01-22^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe0b4bd9779473a24feffffccfde8c14
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publicationDate 2017-11-29^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber KR-20170131365-A
titleOfInvention Antibody-urease conjugates for therapeutic purposes
abstract A pharmaceutical composition comprising an antibody-urease conjugate and substantially free of unbonded urease is disclosed. These compositions are prepared in a manner that does not require chromatographic purification. These pharmaceutical compositions have utility in the treatment of cancer by antibody-directed enzyme prodrug therapy, wherein urease converts endogenous urea to ammonia in situ to induce cytotoxicity.
priorityDate 2015-01-23^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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