http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20190123257-A

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filingDate 2017-11-28^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2019-10-31^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber KR-20190123257-A
titleOfInvention Viral Vector Constructs for the Expression of Gene Adjuvant Activating the STING Pathway
abstract Viral vectors are provided for use as gene immunotherapy agents, including compositions for enhancing cellular immune responses as well as prophylactic and therapeutic vaccines. Such vectors are particularly useful for treating or preventing cancer and infectious diseases. The vector comprises a lentiviral vector capable of encoding one or more antigens and adjuvants and optionally encoding one or more soluble checkpoint inhibitor molecules. Adjuvants are fusion proteins comprising Epstein Barr virus-derived latent membrane protein 1 (LMP1) in which the intracellular domain has been replaced with human IPS1 or a variant thereof capable of activating the STING pathway. Vector-coded sequences are codon optimized for human expression.
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http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP06819
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID415961248
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP06845
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP14679
http://rdf.ncbi.nlm.nih.gov/pubchem/taxonomy/TAXID11072
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID411320080
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID15977
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID4369021
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID411320081
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID15978
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID3456
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP03468
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID411320082
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID3458
http://rdf.ncbi.nlm.nih.gov/pubchem/taxonomy/TAXID11309
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID13349
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID64896714
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID2532
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ5PY51
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID733575
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID415746509
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP03230
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID929
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID23650514
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP10145
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID411320146
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO55159
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP13713
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID396054
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID17773480
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP06906
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http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA9A6M9
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID311430
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID412230686
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID60350
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO70372
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID5354
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID73755215
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID419533319
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID414016161
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID11321969
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID7009558
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID419556335
http://rdf.ncbi.nlm.nih.gov/pubchem/taxonomy/TAXID55194
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID1549440
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO70695
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID733532
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID403801
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID9308
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID7009577
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID516979
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID7009579

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