| abstract |
The present invention is N-(phenyl)-2-(phenyl)pyrimidine-4 of formula I as a hematopoietic progenitor kinase 1 (HPK1) inhibitor for treating cancer, such as breast cancer, colorectal cancer, lung cancer, ovarian cancer, and pancreatic cancer. -Relates to carboxamide derivatives and related compounds. Preferred compounds are, for example, N-(5-fluoro-2-(2-(pyridin-2-yl)pyrrolidin-1-yl)phenyl)-2-(2-fluoro-6-methoxyphenyl )Pyrimidine-4-carboxamide and N-(5-fluoro-2-(hexahydropyrrolo[3,4-b]pyrrole-1(2H)-yl)phenyl)-2-(2-fluoro Rho-6-methoxyphenyl)pyrimidine-4-carboxamide. |