| abstract |
Interleukin-34 is a cytokine involved in the differentiation and survival of macrophages, monocytes, and dendritic cells in response to inflammation. The relevance of IL-34 has been shown in a variety of areas, such as neuroprotection, autoimmune diseases, infection, cancer and transplantation. A recent study also demonstrated a novel and possible therapeutic role for IL-34 as a mediator of transplant-resistant Foxp3 + regulatory T cell secretory cytokines. Accordingly, we have created a novel mutated IL-34 polypeptide that can be used as an agonist or antagonist. |