| abstract |
Provided herein are compositions, systems, and methods for delivering a cargo to a target cell. The compositions, systems, and methods include one or more polynucleotides encoding one or more endogenous retroviral components to form a delivery vesicle and one or more capture moieties for packaging a cargo within the delivery vesicle. The one or more endogenous retroviral components for forming the delivery endoplasmic reticulum may comprise two or more retroviral gag proteins, retroviral envelope proteins, retroviral reverse transcriptases, or combinations thereof. The retroviral gag protein alone, the retroviral envelope protein alone, or both the retroviral gag protein and the retroviral envelope protein may be endogenous. |