| abstract |
The present invention relates to compounds of the general formula (I): (see formula (I)) wherein: R1 represents halogen, CN or NO2; R2 represents hydrogen or halogen; n represents 1 or 2; R3 represents phenyl substituted with one or more halogens or C1-C6 alkyls; or a cyclohexyl; as well as the therapeutically acceptable salts and solvates thereof; These compounds are useful as antagonists of the protease-activated receptor-1 (PAR-1), particularly in the treatment of thrombosis. |