| abstract |
The present invention provides new substituted tricyclic carobxamides that act as competitive oxytocin receptor antagonists, as well as methods for their manufacture, pharmaceutical compositions and methods for use in treatment, inhibition, suppression or prevention of premature delivery, dysmenorrhea, endometriosis, labor suppression. at the end before practicing a caesarean section, and to facilitate antinatal transport to a medical facility. These compounds are also useful for improving fertility rates, improving survival rates and synchronizing the esters in farm animals; and they can be useful in the prevention and treatment of dysfunctions of the oxytocin system in the central nervous system that includes obsessive compulsive diseases (OCD) and neurosychiatric diseases. |