| abstract |
There are disclosed benzene / carboxylic acid diguanidides of formula (I) wherein one of the residues R (1), R (2). R (3) and R (4) represent -CO-N-C (NH 2) 2; and the other residues R (1), R (2), R (3) and R (4) may have different meanings and e.g. for example, R (1) may be hydrogen or alkyl of 1, 2, 3 or 4 C atoms; R (2) and R (4) may independently e.g. means hydrogen, OH, CF3, alkyl of 1, 2, 3 or 4 C atoms, R (3) may e.g. means hydrogen or -OH, R (5) may e.g. means alkyl having 1, 2, 3 or 4 C atoms, F, Cl or CF3. These compounds are valuable antiarrhythmic drugs with cardioprotective components, also for the prevention of ischemic induced damage, especially in the triggering of ischemically induced cardiac arrhythmias. They are used because of the inhibition of the cellular Na + / H + exchanger (n) ekanisroen for the treatment of acute and chronic ischemia-induced injuries. Furthermore, they distinguished themselves by strongly inhibitory effect on cell proliferation. They are suitable for preventing the gene at high blood pressure. |