http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NZ-332975-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_41089a3ea05839b911d9df3e8abde5ea |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C40B40-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00731 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-203 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B40-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-203 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H5-10 |
| filingDate | 1997-11-14^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e63b3479510b793ac91211702ed3edb |
| publicationDate | 2001-06-29^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | NZ-332975-A |
| titleOfInvention | Combinatorial synthesis of carbohydrate libraries |
| abstract | Provided are general synthetic methods for generating very large libraries of diverse thiosaccharide derivatives optionally attached to a solid support. The thiosaccharide derivative libraries are synthesized by reacting a thiosaccharide with a Michael acceptor or an a-halocarbonyl compound (Q-CHR1-C(O) R ) to provide for a thiosaccharide carbonyl compound. The carbonyl group of the thiosaccharide carbonyl compound can optionally be reduced to provide for a plurality of alcohol and/or amine thiosaccharide derivatives. In one embodiment, the alcohol and/or amine group of the thiosaccharide derivative is further derivatized to provide for a plurality of thiosaccharide derivatives. Preferably, the thiosaccharide derivatives are covalently attached to a solid support. Solid supports containing such thiosaccharide derivatives comprise a linking arm which links the solid support to the thiosaccharide derivative. The linking arm can be either cleavable or non-cleavable and when cleavable, can be used to prepare a library of either solid phase or soluble thiosaccharide derivatives. The library of thiosaccharide derivatives, whether soluble or insoluble, can be screened to isolate individual compounds that possess some desired biological activity. In a preferred embodiment, each compound in the library is unique. Figure 1 illustrates a preferred reaction scheme for synthesizing a library of diverse thiosaccharide derivatives using an a,b-unsaturated carbonyl compound, such as cyclohept-2-en- 1-one. |
| priorityDate | 1996-11-15^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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