http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NZ-502866-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a1ca2fe5a1e9022aa0323cbb48d30f5e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-26 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4015 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 1998-09-08^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_12b594b1d8fe53253c445a1e448860da http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d1d49f578ff87726227a5ce35183cba1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_602328e1c2ac8320484821c848bf63f4 |
| publicationDate | 2001-12-21^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | NZ-502866-A |
| titleOfInvention | Substituted 2-pyrrolidinone activators of PKC |
| abstract | A compound of formula I, wherein R' and R2 are each independently (C1-C15)alkyl, (C2-C15)alkenyl, (C2-C15)alkynyl, (C3-C8)cycloalkyl, (C3-C8)cycloalkyl(C1-C10)alkyl, (C3-C8)cycloalkyl(C1-C15)alkenyl, (C3-C8)cycloalkyl(C1-C15)alknyl, (C1-C15)alkoxy, (C1-C15)alkanoyl, (C1-C15)alknoyloxy, aryl, heteroaryl, aryl(C1-C6)alkyl, heteroaryl(C1-C6)alkyl, aryl(C2-C15)alkenyl, heteroaryl(C2-C15)alkenyl, aryl(C2-C15)alkynyl, heteroaryl(C2-C15)alkynyl, aryl(C1-C15)alkoxy, heteroaryl(C1-C15)alkoxy, aryl(C1-C15)alkanoyl, heteroaryl(C1-C15)alkanoyl, aryl(C1-C15)alkanoyloxy, or heteroaryl(C1-C15)alkanoyloxy; wherein any R' or R2 is optionally substituted with one or more substituents independently selected from halo, nitro, cyano, hydroxy, trifluoromethyl, trifluoromethoxy, (C1-C15)alkyl, (C2-C15)alkenyl, (C2-C15)alkynyl, (C3-C8)cycloalkyl, (C3-C8)cycloalkyl(C1-C15)alkyl, (C3-C8)cycloalkyl (C2-C15)alkenyl, (C3-C8)cycloalkyl(C2-C15)alkynyl, (C1-C15)alkoy, (C1-C15)alkanoyl, (C1-C15)alkanoyloxy, C(=O)ORa, C(=O)NRbRc, OC(=O)ORa, OC(=O)NRbRc, and NReRf; and wherein any aryl or heteroaryl of R1 or R2 is optionally substituted on a non-aromatic carbon by a divalent (C2-C7)alkylene chain to form a (C3-C8)spirocycloalkyl; each Ra is independently hydrogen or (C1-C6)alkyl; each Rb and Rc is independently, hydrogen or (C1-C10)alkyl; or Rb, and Rc together with the nitrogen to which they are attached are a 5-6 membered heterocyclic ring; and each Re and Rf is independently hydrogen, (C1-C10)alkyl, (C1-C10)alkanoyl, phenyl, benzyl, or phenethyl; or Re and Rf together with the nitrogen to which they are attached are a 5-6 membered heterocyclic ring; or a pharmaceutically acceptable salt thereof. The compounds find use in treating cancer. |
| priorityDate | 1997-09-08^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Showing number of triples: 1 to 209 of 209.