http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NZ-503759-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_07b71571160c289fbf5fc680dfea513f |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-08 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-71 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C47-575 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D303-48 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D303-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-71 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C43-253 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-275 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C253-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C41-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C41-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C47-575 |
| filingDate | 1998-10-07^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1bdd3fdf07d2e382a0f2024dfb832c88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b598128dd6fa5b24a4c6318335478671 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21bd5b06f551371ad5257554b66bc52f |
| publicationDate | 2002-03-01^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | NZ-503759-A |
| titleOfInvention | Preparation of substituted 4-phenyl-4-cyanocyclohexanoic acids |
| abstract | Compounds of formula I, wherein; R1 is -(CR4R5)nC(O)O(CR4R5)mR6, (CR4R5)nC(O)NR4(CR4R5)mR6, (CR4R5)nO(CR4R5)mR6 or- (CR4R5)rR6, wherein the alkyl moieties may be optionally substituted with one or more halogens; m is 0 to 2; n is 1 to 4; r is 0 to 6; R4 and R5 are hydrogen or C1-2 alkyl ; R6 is hydrogen, methyl, hydroxyl, aryl, halo substituted aryl, aryloxyC1-3 alkyl, halo substituted aryloxyC1-3 alkyl, indanyl, indenyl, C7-11 polycycloalkyl, tetrahydrofuranyl, furanyl, tetrahydropyranyl, pyranyl, tetrahydrothienyl, thienyl, tetrahydrothiopyranyl, thiopyranyl, C3-6 cycloalkyl, or a C4-6 cycloalkyl containing one or two unsaturated bonds, wherein the cycloalkyl and heterocyclic moieties may be optionally substituted by 1 to 3 methyl groups or one ethyl group; X is YR2, halogen, nitro, NH2, or formyl amine; X2 is O or NR8; Y is O or S(O) m ; m' is 0, 1, or 2; R2 is -CH3 or-CH2CH3 optionally substituted by 1 or more halogens; R3 is hydrogen, halogen, C1-4 alkyl, CH2NHC(O)C(O)NH2, halo-substituted C1-4 alkyl, CH=CR8'R8',cyclopropyl optionally substituted by R8', CN, OR8, CH2OR8, NR8R10, CH2NR8R10, C(Z')H, C(O)OR8, C(O)NR8R10, or CºCR8'; R8 is hydrogen or C1-4 alkyl optionally substituted by one to three fluorines; R8' is R8 or fluorine; R10 is OR8 or R11; R11l is hydrogen, or C1-4 alkyl optionally substituted by one to three fluorines; Z' is O, NOR8, NCN, C(-CN)2, CR8CN, CR8NO2, CR8C(O)OR8, CR8C(O)NR8R8, C(-CN)NO2, or C(-CN)C(O)NR8R8; R' and R" are hydrogen or -C(O)OX, where X is lithium or hydrogen; are prepared by: a) combining a Group I (a) or Group II (a) metal halide, with an aprotic dipolar amide-based solvent and water and a compound of formula II (a) or II (b), where R1, R3, X2 and X are as defined above; b) heating the combination to a temperature of at least about 60º for several hours, optionally under an inert atmosphere; c) precipitating out the lithium salt of a compound of formula (I) by adding a lithium hydroxide to the combination; d) removing the amide-based solvent and water from the precipitate, and optionally 1) purifying further the precipitate, or 2) acidifying the precipitate to obtain the free acid. |
| priorityDate | 1997-10-10^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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