| abstract |
Described are benzene-sulphonamide derivatives having the general formula (I), wherein: X represents a nitro, cyano or halogen group, Y1 represents a secondary or tertiary amino group, a sulphur or an oxygen, Y2 represents a -NH group or a nitrogen, Z represents oxygen, sulphur, -N-CN or -CH-NO2, and R1 and R2, which can be identical or different, represent each independently a saturated or unsaturated, linear or branched C2-C12 alkyl group, a saturated or unsaturated C3-C12 alicyclic group, an aryl group optionally substituted by C1-C4 alkyl, nitro, cyano, trifluoromethyl, carboxy and halogen, or an arylalkyl group, or R1 and/or R2 form with Y1 and/or Y2 a saturated or unsaturated 5 to 7 membered heterocyclic group, with the exception of derivatives for which X is a nitro group, Y1 represents a secondary amine group (-NH-), Y2 represents a -NH group, Z an oxygen, R2 an isopropyl and R1 an element selected in a group consisting of (m-toluyl, phenyl and cyclooctyl) and with the exception of N-[(cyclooctylamino-5-cyanobenzene)sulphonyl]-N'-isopropyl urea. Also described is the use of compounds of formula (I) in pharmaceutical preparations for the treatment of illnesses involving the thromboxan A2. |