abstract |
A crystalline monohydrate of (1á, 2â, 4â, 5á, 7â)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane-bromide (tiotropium bromide monohydrate). A process for the production of the abovementioned compound is also disclosed and pharmaceutical compounds having an anticholinergic activity, suitable for the treatment of COPD and asthma. |