| abstract |
A compound of formula I is described wherein: One of R1 and R4 is selected from H, optionally substituted C1-6alkyl, C3-7cycloalkyl, C3-7 cycloalkyl-C1-4alkyl and phenyl C1-4alkyl and the other of R1 and R4 is an optionally substituted C9-14aryl group, wherein the C9-14aryl group has at least 2 fused rings R2 and R3 are selected from R, R', SO2R, C(=O)R, (CH2)nNR5R6, where n is 1 to 4 and R5 and R6 is selected from H and R where R is optionally substituted C1-4alkyl, and R' is optionally substituted phenyl-C1-4alkyl. The compounds can be used in the preparation of medicaments for the treatment of conditions alleviated by antagonism of 5-HT2B receptors. |