| abstract |
Disclosed is a diphenylethylene compound of formula (I) or a pharmaceutically acceptable salt, solvate or hydrate thereof, wherein the substituents are described within the specification. Also disclosed is the use of the above compound for the preparation of a composition for inhibiting angiogenesis, for inhibiting or reducing tubulin polymerization or tubulin stability in a cell, for inhibiting PDE4 activity in a cell, for treating or ameliorating an inflammatory disorder, for inhibiting or ameliorating cancer and for treating or ameliorating a central nervous system disorder. |