| abstract |
Disclosed is crystalline anhydrous form C of moxifloxacin hydrochloride characterised by having an XRPD with peaks at 10.24, 15.08, 17.21, 24.60, 25.06, 26.42, 27.86, 28.22, 28.88 and 29.85 ± 0.2 °2q, and which also exhibits a melting endotherm peak at 253°C as measured by differential scanning calorimetry (10.00 ºC/minute). Further disclosed is a method of making moxifloxacin hydrochloride form C as defined above which comprises dissolving or suspending moxifloxacin base in methanol; treating the solution with methanolic hydrochloric acid; isolating the resulting moxifloxacin hydrochloride; and drying said moxifloxacin hydrochloride under vacuum at 80 - 90°C to obtain Form C. |