http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NZ-581165-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a9e6421e9257148abad101e1ce6c162 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_67dd1f39f37bac4617e37d6d5c60aa8b |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-513 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-00 |
| filingDate | 2008-05-14^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bb568e65192f99f1883eb4293d1449d2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa0894d3f3252c5b05b764235574164c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4c0fbbf35890bb2593b9c36a3b11c19f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_427a5793aeb3a72c2ff86856851b89dc |
| publicationDate | 2011-09-30^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | NZ-581165-A |
| titleOfInvention | Heteroarylamide pyrimidone compounds |
| abstract | Disclosed is a pyrimidone derivative represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof wherein: X represents two hydrogen atoms, a sulphur atom, an oxygen atom or an alkyl group and a hydrogen atom; Z represents a bond, an oxygen atom, a nitrogen atom substituted by a hydrogen atom or an alkyl group, a sulphur atom, a methylene group; R1 represents a 2, 4 or 5-pyrimidine ring or a 4-pyridine ring; R2 represents a heterocyclic group, R3 represents a hydrogen atom, an alkyl group or a halogen atom; R4 represents a hydrogen atom or an alkyl group; R5 represents a hydrogen atom, an alkyl group; R7 represents a hydrogen atom or an alkyl group; and n represents 0 to 3 and m represents 1 in the form of a free base or of an addition salt with an acid exemplified by [1,5]Naphthyridine-2-carboxylic acid [Z-(1-methyl-6-oxo-1,6-dihydro- [4,4']bipyrimidinyl-2-yl)-ethyl]-amide, 6-Chloro-pyridine-2-carboxylic acid [Z-(1-methyl-6-oxo-1,6-dihydro- [4,4']bipyrimidinyl-2-yl)-ethyl]-amide and 2-Methoxy-N-[2-( 1-methyl-6-oxo-1 ,6-dihydro-[4,4']bipyrimidinyl-2-yl)-ethyl]-amide in treating Alzheimer's disease, Parkinson's disease, tauopathies, vascular dementia; acute stroke, traumatic injuries; cerebrovascular accidents, brain cord trauma, spinal cord trauma; peripheral neuropathies; retinopathies or glaucoma, noninsulin dependent diabetes; obesity; manic depressive illness; schizophrenia; cancers; parenchymal renal diseases or muscle atrophy and malaria. Also disclosed is a process to make said derivative by coupling a pyrimidone amine with a carboxylic acid derivative in basic conditions. |
| priorityDate | 2007-05-16^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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