| abstract |
REFERS TO DERIVATIVES OF THIAZOL-BENZOISOTHIAZOLE DIOXIDE SUBSTITUTED FOR FORMULA I, INCLUDING ITS PHYSIOLOGICALLY ACCEPTABLE SALTS, WHERE R1 AND R2 ARE, INDEPENDENTLY BETWEEN IF, H, ARYL, COOH, ALKYLEN- (C1-OH, ALKYLEN- -ALKYL (C1-C6), AMONG OTHERS; R3 IS H, C1-C6 ALKYL, (C1-C6) -ARYL ALKYL, C (O) -ARYL, AMONG OTHERS; R4 AND R5 ARE H, F, Cl, Br, ALKYL- (C1-C6), CF3, OCF3, AMONG OTHERS; R6 IS H, F, Cl, Br, C1-C6 ALKYL, CYCLOPROPYL, AMONG OTHERS; o R6 AND R7, TOGETHER, FORM THE GROUP = CH2. ALSO REFERS TO A MEDICINAL PRODUCT THAT INCLUDES ONE OR MORE COMPOUNDS DERIVED FROM FORMULA I, AND AT LEAST ONE OTHER ADDITIONAL ACTIVE INGREDIENT. THE MENTIONED COMPOUNDS INHIBIT THE ACTIVITY OF PHOSPHTHYROSINE 1B PHOSPHATASE (PTP1B) AND ARE USEFUL TO REDUCE GLUCOSE IN THE BLOOD AND FOR THE PREVENTION AND TREATMENT OF DIABETES |