| abstract |
REFERS TO COMPOUNDS DERIVED FROM 6-HETEROARYLPYRIDOINDOLONE OF FORMULA (I) WHERE R1 IS H, ALKYL (C1-C4), CN, CF3 OR CHF2; R2 IS H O (C1-C4) ALKYL; R3 IS PHENYL OPTIONALLY SUBSTITUTED WITH ALKYL HALOGEN OR ALCOXY (C1-C4); R4 IS A SELECTED HETEROCYCLIC OF 1,3-THIAZOLE, 1,3,4-THIAZOLE, PIRAZOLE, OXAZOLE, ISOXAZOLE AMONG OTHERS SUBSTITUTED BY R7; R5 IS H, HALOGEN, ALKYL, OR ALCOXY (C1-C4). THE PREFERRED COMPOUNDS ARE: 3- (2,4-DICHLOROPHENYL) -1-METHYL-6- (2-METHYL-1,3-THIAZOL-4-IL9-1,9-DIHYDRO-2H-PIRIDO 2,3-b INDOLE -2-ONA, 6- (2-AMINO-1,3-THIAZOL-4-IL) -3- (2,4-DICHLOPHENYL) -1-METHYL-1,9-DIHYDRO-2H-PYRID 2,3b INDOLE -2-ONA, AMONG OTHERS, ALSO REFERS TO A PHARMACEUTICAL COMPOSITION AND A PREPARATION PROCEDURE. THESE COMPOUNDS ARE INHIBITORS OF THE PROLIFERATION OF TUMOR CELLS AND ARE USEFUL IN THE TREATMENT OF NEOPLASMAS, CARCINOMAS, SARCOMAS, CARCINOMAS OTHERS |